摘要
本文报道在马里共和国某医院工作期间,采用不同剂量吡喹酮治疗1627例埃及血吸虫病患者的临床疗效。甲组1187例,给以40mg/k,顿服;乙组321例,给以10mg/kg,日服3次,连服2d;丙组119例,给以50mg/kg,顿服。治疗后3个月,镜检尿内虫卵,3组比较,以乙组疗法的疗效为最佳,虫卵阴转率达96.6%,表明吡喹酮分次给药的方案较单次顿服为佳,且无药物副作用。
A total of 1 627 cases of scmstosomiasis haematobium had been treated with praziquan-tel of different dosages by the Chinese Medical Team in Mali.The patients were all con-firmed by egg detection in urine examination and were divided into three groups.Group A,1187 cases,were each given a single dose of 40 mg/kg of praziquantel.In Group B,321 cas-es,were each treated with 10 mg/kg of praziquantel,t.i.d.for two days.In Group C,119cases,were each administered with one dose of 50 mg/kg of praziquantel.Three months af-ter treatment,the urine egg negative conversion rates were 88.5%,96.6% and 89.1%,re-spectively.It was showed that Group B gave the best efficacy and produced fewer side ef-fects,suggesting that the regime of praziquantel treatment given in divided doses is betterthan that given at a single dose.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
1994年第4期288-290,共3页
Chinese Journal of Parasitology and Parasitic Diseases