埃索美拉唑联合莫沙必利治疗反流性食管炎疗效观察

Efficacy of esomeprazole and mosapride in treatment of reflux esophagitis

目的 探讨埃索美拉唑联合莫沙必利治疗反流性食管炎的临床疗效。方法 将90例经内镜证实的反流性食管炎患者随机分成埃索美拉唑联合莫沙必利组(A组)、埃索美拉唑组(B组)和莫沙必利组(C组) ,三组分别采用:埃索美拉唑4 0mg ,口服,1/d ,莫沙必利5mg ,口服,3/d治疗;以及单独口服以上二药治疗,疗程6周,停药后复查胃镜,观察镜下治愈率,并记录症状改善情况及不良反应。结果 治疗6周后,联合组、埃索美拉唑组、莫沙必利组的症状改善总有效率分别为96 .7%、86 .7%、6 6 .7% ,胃镜下有效率分别为93.3%、83.3%、4 6 .7% ,各组间相比均有显著性差异(P <0 .0 5 )。结论 埃索美拉唑联合莫沙必利治疗反流性食管炎,有较高的治愈率和症状改善率,临床疗效明显优于单用埃索美拉唑、莫沙必利。

Objective To investigate the effect of esomeprazole and mos apride in the treatment of reflux esophagitis.Methods Ninety pa tien ts with endoscopically proven reflux esophagitis were randomly divided into thre e groups.Group A received esomeprazole 40 mg once daily and mosapride 5 mg three times daily. Group B received esomeprazole 40 mg once daily. Group C received mosapride 5 mg three times daily.After 6 weeks, endoscopy was performed to study the healing rate. Improvement in symptoms and adverse effects were recorde d.Results〓After 6 weeks treatment, the total symptom improvemen t rates in groups A,B and C were 96.7%,86.7% and 66.7%,resfectively;the endos copic healing rates were 93.3%,83.3% and 46.7%,resfectively.There were significa nt differences in total symptom improvement rates and endoscopic healing rates b etween the three groups(P<0.05).Conclusion Esomeprazole co mbined with mosapride is highly effective in the treatment of reflux esophagiti s.