胆固醇酯转运蛋白TaqIB基因多态性与冠心病的关系

Relationship of Taq IB Polymorphism in the Cholesteryl Ester Transfer Protein Gene to Coronary Artery Disease

目的 分析胆固醇酯转运蛋白TaqIB基因多态性与冠心病的相关性。方法 选择确诊的冠心病病人 ,自全血中抽提基因组DNA后 ,用聚合酶链反应—限制片长多态性方法检测胆固醇酯转运蛋白TaqIB基因型。以χ2 检验和Logistic多因素回归分析作统计学差异检验。 结果 冠心病组和对照组的胆固醇酯转运蛋白TaqIB基因型和等位基因频率分布均差异无显著性。进一步进行性别及心肌梗死型和非心肌梗死型冠心病分层分析亦差异无显著性。

Aim To elucidate the relationship of Taq IB polymorphism in the cholesteryl ester transfer protein (CETP) gene and coronary artery disease(CHD). Methods Taq IB polymorphism in the cholesteryl ester transfer protein gene was analysed in 88 patients and 94 controls. The polymorphism was determined by polymerase chain reaction(PCR)-restriction fragment length polymorphism(RFLP) using genomic DNA from anti-coagulantion blood. χ 2 test and Logistic regression analysis were used. Results There are no defferences in both alle frequency and genotype distribution of cholesteryl ester transfer protein gene between patients and control groups. Conclusion The Taq IB polymorphism in the cholesteryl ester transfer protein gene doesn't contribute to coronary artery disease.