^(32)磷血管内照射、舒降之和波立维联用预防血管再狭窄

Experimental Study of Endovascular Irradiation Associated with Simvastatin and Clopidogrel on Restenosis after Interveneional Therapy

目的 观察动脉粥样硬化新西兰白兔髂动脉球囊损伤后3 2 磷血管内照射、波立维和舒降之联用对损伤部位再狭窄的影响。方法 复制新西兰白兔动脉粥样硬化狭窄模型,各时间点处死动物,免疫组织化学法检测基质金属蛋白酶2、增殖细胞核抗原和α肌动蛋白水平,并进行定量统计分析。结果 联合组较单纯组各时间点管腔面积明显增大,新生内膜面积明显减少(P <0 .0 5 ) ;各时间点基质金属蛋白酶2、增殖细胞核抗原和α肌动蛋白表达依次明显降低,联合组表达最低(P <0 .0 5 )。结论 3 2 磷血管内照射、波立维和舒降之联用对血管平滑肌细胞增殖有一定抑制作用。

Aim To evalvate the effects of endovascular irradiation associated with simvastatin and clopidogrel on restenosis after interveneional therapy. Methods 72 male New Zealand white rabbits were studied. Except those in normal control group, other rabbits were made into athetoscletosis and restenosis modles. Immunohistochemistry method was used to detect the data expressed in the vascular. The expression were analyzed by image analysis. All these collected data were analyzed using factorial ANOVA. Results At each time point, the lumem area was larger and the neointima area was smaller in associated group than in other groups(P<0.05). The expression of matrix metalloproteinase-2(MMP-2), proliferation cell nuclear antigen(PCNA), α-SM actin in the vascular in the iliac arteries of associated group is the least (P<0.05). Conclusion 32 P irradiation associated with simvastatin and clopidogrel has the effect of preventing restenosis after balloon injury.