老年下肢动脉粥样硬化在糖尿病患者中的病理特点

The Pathology Characteristic of Femoral Atherosclerosis in Elder Diabetes Patients

目的 探讨老年糖尿病患者下肢动脉粥样硬化的病理特点。方法 收集老年糖尿病尸体解剖病例8例,并设立对照组,将所有病例的两侧股动脉进行连续取材,常规病理检查,其中部分节段行α平滑肌肌动蛋白、CD6 8和bax染色。结果 与对照组比较,糖尿病组股动脉粥样硬化程度更重,钙化范围更大;其斑块中的平滑肌细胞相对较少,巨噬细胞相对较多;bax在巨噬细胞的表达较多,在平滑肌细胞的表达减少。结论 提示糖尿病可能促进了股动脉粥样硬化的发生、发展。

Aim To investigate the pathology characteristic of femoral atherosclerosis in elder diabetes patients. Methods 8 elder diabete autopsy cases and 8 control cases were selected respectively in our hospital. Serial sections of femoral artery of all cases were taken. All the arteries were examined, and parts of the segments were selected for immunohistochemical staining. Three markers against α-smooth muscle actin, CD68, and bax were performed. Results Compared with control cases, the femoral atherosclerosis was more serious and the calcify range was wider in diabete patients; there were less smooth muscle cells and more macrophage in femoral atherosclerotic plaques, and the expression of bax in macrophages was stonger, the expression of bax in smooth muscle cell was weaker. Conclusions Diabete may accelerate the occurrence and development of femoral atherosclerosis.