三联药物治疗异位妊娠的临床研究

Clinical study of co-triplex drugs used in treatment of ectopic pregnancy

目的:寻找一种简便、有效、成功率高、毒副反应小又不影响生育功能的异位妊娠的药物治疗方法。方法:对112例未破裂型异位妊娠病人,按药物治疗方法不同分两组进行对照研究,A组使用甲氨蝶呤(MTX)+米非司酮(Ru486)+中药联合治疗;B组使用MTX+Ru486治疗。结果:血绒毛膜促性腺激素(β-HCG)下降及病灶包块缩小或消失A组均比B组明显改善(P<0.01);平均住院日A组比B组明显缩短(P<0.001);副反应发生率A组比B组明显减少(P<0.01);A、B两组第一疗程有效率和总有效率分别为85.7%、55.4%和98.2%、80.4%(P均<0.01)。结论:MTX+Ru486+中药三联药物治疗未破裂型异位妊娠具有方法简便、疗效高、疗程短、副作用小、保留生育功能等优点,值得临床推广应用。

Objective:To find an easy and effective method with high successful rate without influence on bearing function.Methods:112 cases of patients with unruptured ectopic pregnancy were divided into groups A 〔treated with Methotrexate (MTX)+Mifepristone (Ru486)+Chinese herbs〕 and B (MTX+Ru486).Results:The decrease ofβ-HCG concentration and reduction or disappearence of focus mass in group A were significantly than those of group B (P<0.01); The average hospitalization days of group A was shorter than that of group B (P<0.01); The occurrence rate of side effect in group A was significantly less than that of group B (P<0.01); The effective rate in the first period of treatment and total effective rates of group A and B was 85.7%, 55.4% and 98.2%, 80.4%, respectively (P<0.01).Conclusion:Co-triplex drugs treatment was convenient, efficacious and safe therapy with less side effect and shorter treatment period for patients with unruptured ectopic pregnancy, which should be used widely in clinical therapy.