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脑源性神经营养因子研究进展及在儿科的应用 被引量：6

Progress in study on BDNF and its application in pediatrics
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摘要 阐述脑源性神经营养因子通过与其相应的受体trkB结合发挥生理作用 ,及其促进和维持神经细胞功能的生物学效应的研究 ,进一步探讨脑源性神经营养因子在儿科临床的应用。 The review clarified study on biological effects of BDNF through binding to it 's specific receptor trkB, that is, improving and maintaining the function of ne uron. Also, we explored the application of BDNF in pediatrics.
作者 丁辉 何平
机构地区 昆明医学院附属二院儿科
出处 《国外医学（妇幼保健分册）》 2005年第1期13-15,共3页 Foreign Medical Sciences (Section of Maternal and Child Health)
关键词 脑源性神经营养因子 儿科 brain-derived neuotrophic factor(BDNF) pediat rics
分类号 R977.9 [医药卫生—药品] R72 [医药卫生—儿科]
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参考文献19

  • 1von Bartheld C S, Johnson J E. Target-derived BDNF (brain-derived neurotrophic factor) is essential for the survival of developing neurons in the isthmo-optic nucleus[J]. J Comp Neurol,2001,433:550-564.
  • 2Balkowiec A, Katz D M. Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ[J]. J Neurosci,2000,20:7417-7423.
  • 3Murer M G, Yan Q, Raisman V R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease[J]. Prog Neurobiol,2001,63:71-124.
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  • 5Patapoutian A, Reichardt L F. Trk receptors: mediators of neurotrophin action[J]. Curr Opin Neurobiol,2001,11:272-280.
  • 6Minichiello L, Calella A, Medina D, et al. Mechanism of TrkB-mediated hippocampal long-term potentiation[J]. Neuron,2002,36:121.
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  • 8Egan M F, Kojima M, Callicott J H, et al. The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function[J]. Cell,2003,112:257-269.
  • 9Patterson S L, Pittenger C, Morozov A, et al. Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase[J]. Neuron,2001,32:123-140.
  • 10Poo M M. Neurotrophins as synaptic modulators[J]. Nat Rev Neurosci,2001,(2):24-32.

同被引文献110

引证文献6

二级引证文献43

国外医学（妇幼保健分册）
2005年 第1期

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