儿童中枢性性早熟的治疗思路与实践

Idea and practice of treatment for children central precocious puberty

主要阐述了促性腺激素释放激素类似物治疗儿童中枢性性早熟的理论基础 ,现认为促性腺激素释放激素类似物是治疗儿童中枢性性早熟病人的一种选择 ,其有效地抑制了性腺的发育并延缓了骨成熟的速度 ,但是这些病人的成年身高常低于遗传趋势的预期值。这激发人们研究生长激素与促性腺激素释放激素类似物联合应用是否提高成年后的身高 ,该文对近期一些相关的理论及联合实验结果进行了分析。

This article mainly reviewed theoretical basis of treatment with go nadotropin releasing hormone analogue (GnRHa) for children central precocio us puberty (CPP). Recently, GnRHa was considered to represent a new therapy alt e rnative for children with CPP, which can effectively arrest pubertal devel opment and slow down bone maturation. However, in some patients, the adult heigh t is usually lower t han the target height predicted by their genetic trend. For this reason some inv estigators suggested to study whether the combination use of growth hormone (GH) with GnRHa could increase adult height. This article analyzed some recent relat ed theories and results of several studies in this field.