水通道蛋白调节的研究进展

Progress in study on regulation of aquaporins

水通道蛋白是特异性跨膜转运水的蛋白家族 ,能显著增加细胞膜水通透性 ,参与水的分泌、吸收及细胞内外水的平衡。迄今为止 ,在哺乳动物细胞膜上已发现 11种水通道蛋白 ,这些水通道蛋白分别介导不同类型细胞膜的跨膜水转运 ,使水代谢的研究进入了一个新的领域。

Aquaporins are a family of transmembrane water-specific proteins that can great ly enhance permeability of the membrane for water by which they take part in sec r etion, absorption of water and balance between intra-and extracellular fluids. To date,at least 11 types of mammalian aquaporins that respectively mediate transmembrane water movement i n different types of cells have been identified,which brings the study on water metabolism to a new field.