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NES1基因与肿瘤研究 被引量:1

NES1 gene and cancer research
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摘要 正常上皮细胞特异性-1(NES1)基因,又称人组织激肽释放酶10(KLK10),是近年来新发现的一种抑癌基因,其编码的蛋白序列与丝氨酸蛋白酶高度同源,在调控正常上皮细胞生长、分化等方面起一定作用。最近研究还发现,NES1基因甲基化与多种肿瘤的发生有关,其表达产物对肿瘤患者的早期诊断、病情监测、估计预后、疗效评价等具有重要作用。
作者 黄玮 钟捷
出处 《国外医学(肿瘤学分册)》 2005年第5期345-347,共3页 Foreign Medical Sciences (Cancer Section)
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参考文献16

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同被引文献20

  • 1吴健民.对肿瘤标志物的再认识[J].中华检验医学杂志,2005,28(1):11-13. 被引量:116
  • 2李巧云,史惠蓉,颜秋梅.人激肽释放酶蛋白14在宫颈癌中的表达[J].第三军医大学学报,2007,29(14):1449-1450. 被引量:1
  • 3缪懿,严沁,万小平.人组织激肽释放酶10与妇科恶性肿瘤的研究进展[J].现代妇产科进展,2007,16(7):542-544. 被引量:2
  • 4Liu XL,Wazer DE,Watanabe K. Identification of a novel serine protease-like gene,the expression of which is down-regulated during breast cancer progression[J].Cancer Research,1996,(14):3371-3379.
  • 5Kioulafa M,Kaklamanis L,Stathopoulos E. Kallikrein 10(KLK10)methylation as a novel prognostic biomarker in early breast cancer[J].Annals of Oncology,2009.1020-1025.
  • 6Dhar S,Bhargava R,Yunes M. Analysis of Normal Epithelial Cell Specific-1(NES1)/Kallikrein 10 mRNA Expression by in Situ Hybridization,a Novel Marker for Breast Cancer[J].Clinical Cancer Research,2001,(11):3393-3398.
  • 7Zhang Y,Bhat I,Zeng M. Human kallikrein 10,a predictive marker for breast cancer[J].Biological Chemistry,2006,(06):715-721.doi:10.1515/BC.2006.090.
  • 8Luo LY,Bunting P,Scorilas A. Human kallikrein 10:a novel tumor marker for ovarian carcinoma[J].Clinica Chimica Acta,2001.111-118.
  • 9Shvartsman HS,Lu KH,Lee J. Overexpression of kallikrein 10 in epithelial ovarian carcinomas[J].Gynecologic Oncology,2003.44-50.
  • 10Luo LY,Katsaros D,Scorilas A. The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis[J].Cancer Research,2003,(04):807-811.

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