普伐他汀调脂治疗对老年冠心病患者冠脉血流储备的影响

Effect of Pravastatin on Coronary Flow Reserve in Elderly Patients with Coronary Heart Disease

目的:应用彩色多普勒超声仪,观察老年冠心病(ECHD)患者冠状动脉血流储备(CFR)的变化及普伐他汀治疗后对其影响。方法:28例健康志愿者为对照组,25例ECHD患者为治疗组,比较两组的血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血浆内皮素-1(ET-1)及CFR(=潘生丁注射后患者冠状动脉最大血流速度/静息状态时的基础血流速度),并比较普伐他汀治疗前后上述各项指标。结果:治疗前ECHD患者TC、LDL-C及ET-1水平显著高于对照组(P均<0.01),CFR低于对照组(P<0.01);经普伐他汀治疗6月后,TC,LDL-C及ET-1水平均明显降低(P均<0.05),而CFR明显升高(P<0.05)。结论:普伐他汀治疗可有效地降低ECHD患者TC及LDL-C水平,改善患者的CFR。

Objective: To investigate the coronary flow reserve (CFR) in elderly patients with coronary heart disease (ECHD) and the effects of Pravastatin on CFR. Method: 28 healthy subjects as control group and 25 ECHD patients as treatment group were studied. The total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), endothelin-1 (ET-1) and coronary flow reserve (CFR) were all examined pre-and post-therapy with Pravastatin. Results: The concentrations of TC, LDL-C and ET-1 in treatment group before therapy with Pravastatin are significantly higher than those in control group (all P<0.01), and the CFR is lower obviously (P < 0.01). After therapy with Pravastatin for 6 months, the concentrations of TC, LDL-C and ET-1 are lowered evidently (P<0. 05) while the CFR is significantly increased (p< 0. 05). Conclusion: The concentrations of TC, LDL-C of ECHD may be effectively reduced by therapy with Pravastatin and the CFR may be greatly improved.