摘要
冠心病是一种高发病率和高病死率的疾病,炎症反应在冠状动脉粥样硬化斑块的形成中起着重要作用。活化的血管内皮细胞分泌的细胞黏附分子,如细胞间黏附分子-1和E-选择素等,它们介导内皮细胞与白细胞、血小板间的起始黏附,促进血液循环中白细胞、血小板黏附于血管内皮,引起炎症反应、血栓形成等,在动脉粥样硬化和冠心病的发生、发展中起重要作用。
Coronary heart disease has a high incidence and high death rate.Inflammation and immunity play important roles throughout all stages of coronary heart disease.The intercellular adhesion molecule-1(ICAM-1)and E-selectin,which play fundamental roles in inflammation processes and are the earliest events in the pathogenesis of coronary atherosclerosis.They mediate adhesion of circulating leukocytes and platelets to the activated endothelium.
出处
《心血管病学进展》
CAS
2005年第3期278-281,共4页
Advances in Cardiovascular Diseases
基金
教育部留学人员回国基金资助教外司留[2002]247号(No.697)
