氧代创新霉素中间体合成研究

STUDIES ON SYNTHESIS OF 5-OX-CHUANGXINMYCIN INTERMEDIATES

创新霉素是我国发现的一个具独特结构的新抗生素，经结构改造后的部分化合物具有不同程度的抗瘤活性。本文合成制得六种新的氧代创新霉素中间体，为氧代创新霉素的合成打下了基础。

Chuangxinmycin,first antibiotic founded in our country,is a new kind of antibiotic structure,Several analogues of antitumor acti-vity were now synthesized through structural modification from Chuangxi-nmycin,We have synthesized six new 5-oxa-Chuangxinmycin intermedia-tes and provided a basis for further synthesizing of the likes.