链霉菌FM41产生的克拉维烷类新化合物──β—内酰胺酶抑制剂FM41

β LACTAMASE INHIBITOR FM41,A NEW MEMBER OF THE CLAVAM GROUP PRODUCED BY STREPT OMYCES SP.FM41 ISOLATED FROM SOIL SAMPLES IN CHINA

自福州土壤分离的β—内酰胺酶抑制剂ＦＭ４１产生菌，链霉菌ＦＭ４１经形态、培养特征和生理特性与克拉维酸产生菌俸状链霉菌直接对照比较，证明链霉菌ＦＭ４１与棒状链霉菌十分相似。链霉菌ＦＭ４１的代谢产物ＦＭ４１经理化性质和体外生物学活性研究，表明它与克技维酸和已知的克拉维烷类化合物不同，可能是克拉维烷类中的新成员，其化学结构正在研究中。

β lactamase inhibitor FM41 producing strain,Streptomy-ces sp,FM41,was isolated from soil samples in Fuzhou,China,The pr-operties of strain FM41 in morphology,cultural characteristics and physi-ological properties as well as carbon utilization were compared with thatof Streptomyces clavuligerus which produces Clavulanic acid.The identif- ication studies show Streptomyces FM41 to be similar to Streptomyces cla-vuligerus.The physico-chemical properties and the biological properties of β la-ctamase inhibitor FM41 were compared with Clavulanic acid and it showsthat β lactamase inhibitor FM41 differs from Clavulanic acid and theknown derivatives of clavam group,It may be a new member of clavam group and the stndy of chemical structure of FM41 is in progress.