血清降钙素原和白细胞介素6检测对中枢神经系统感染的诊断意义

Clinical Significance in Determination of Changes in Serum Procalcitionin, Interleukin-6 in Nerve Centre Infections Diseases

目的:探讨降钙素原(PCT)和白细胞介素6(IL6)在中枢感染性疾病中的价值。方法:采用微量免疫发光法和夹心ELISA法检测62例各种中枢感染患者及36例健康者的血清降钙素原和白细胞介素6的水平。结果:化脓性脑膜炎(化脑)血清PCT及IL6的结果分别为(54.36±8.44)μg/L、(119.2±9.89)pg/ml。病毒性脑膜炎(病脑)血清PCT及IL6的结果为(0.69±0.26)μg/L、(6.73±1.77)pg/ml,对照组结果分别为(0.37±0.19)μg/L、(3.15±1.03)pg/ml,化脑组与病脑组比较,PCT及IL6结果均有显著性差异(P<0.05),化脑组PCT与对照组比较有显著性差异(P<0.05),病脑组与对照组比较PCT无显著性差异(P>0.05)。结论:PCT可作为区别化脑与病脑的一项重要指标,可以指导临床对中枢感染的诊治。

Objective: To explore the clinical siginificance in the determination of the changes in serum procalcitionin (PCT), interleukin-6(IL-6) in nerve centre infections diseases. Methods: PCT and IL-6 detected in 62 hospitalized cases with different nerve centre infections diseases by immunoluminometric assay and sandwich ELISA, and 36 heath group were detected as normal control. Results: The level of serum PCT and IL-6 in cases with purulent meningits was (54.36±8.44)μg/L、(119.2±9.89)pg/ml, the level of serum PCT and IL-6 in cases with viral encephalitis was (0.69±0.26)μg/L、(6.73±1.77)pg/ml,the serum level of PCT and IL-6 in control group was (0.37±0.19)μg/L、(3.15±1.03)pg/ml. As compared the purulent meningits with the viral encephalitis, there were siginificant difference in serum PCT and IL-6 (P<0.05), and while compared with the viral encephalitis with the control group there were no siginificant difference in serum PCT and IL-6 (P>0.05). Conclusion: PCT could be proposed as one of important differential marker in purulent meningits and viral encephalitis. It should be an instruction in diagnosis treatment and prognosis monitoring of nerve infections diseases.