摘要
The first asymmetric synthesis of (+)-methyl cembra-1,3,7,11-tetraene-16-carboxynate, a naturally occurring cembrane-type macrocyclic diterpene isolated from Sinularia mayi, was achieved via general approach by employing an intramolecular McMurry coupling and Sharpless asymmetric epoxidation as the key steps from readily available starting materials. The synthesis presented here verifies that the absolute configuration of compound 1 was assumed as 15R.
The first asymmetric synthesis of (+)-methyl cembra-1,3,7,11-tetraene-16-carboxynate, a naturally occurring cembrane-type macrocyclic diterpene isolated from Sinularia mayi, was achieved via general approach by employing an intramolecular McMurry coupling and Sharpless asymmetric epoxidation as the key steps from readily available starting materials. The synthesis presented here verifies that the absolute configuration of compound 1 was assumed as 15R.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2005年第5期880-882,F011,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20072012)
高校博士学科点基金资助.
关键词
西松烷型大环二萜
天然产物
不对称合成
Cembrane-type macrocyclic diterpene
Natural product
Asymmetric synthesis
