贲门癌患者术前术后化疗的临床研究

Clinical study of pre-and post-operative chemotherapy in patients with gastric cardial cancer

目的探讨贲门癌术前术后化疗的疗效。方法贲门癌患者121例随机分为术前术后化疗(A)组,单一手术(B)组。A组患者术前1周连续化疗两次,术后第1、2、8、9天各化疗1次,患者出院后口服替加氟3个月,B组单纯手术治疗。结果A、B两组1年生存率分别为94.4%和90.6%,3年生存率分别为61.1%和39.1%,5年生存率分别为33.3%和21.9%,10年生存率分别为13.0%和7.8%,A、B两组3年生存率差异有显著性,1,5,10年生存率差异均无显著性。结论术前术后化疗能显著提高贲门癌患者的3年生存率,5,10年生存率也有明显提高,疗效优于单纯手术组。

Objective To evaluate the long-term therapeutic results of pre-and post-operative chemotherapy for gastric cardial cancer.Methods 121 patients were divided randomly into pre-and post-operative chemotherapy group(group A)and only operation group(Group B).The patients in group A received chemotherapy two times one week before operation and on days 1,2,8,9 after operation.After they were discharged from hospital,they took chemotherapy drugs for 3 months.Results The 1-,3-,5- and 10-year survival rates of the patients in group A were 94.4%,61.1%,33.3% and 13.0% respectively.The 1-,3-,5-and 10-year survival rates of the patients in group B were 90.6%,39.1%,21.9%,7.8% respectively.The 3-year survival rate in group A was much higher than that in group B(P<0.05).There was no significant difference in 1-,5- and 10-year survival rates between the two groups.Conclusion There was notable increase in the 3-year survival rate of the patients in group A(P<0.05).There was also increase in the 5- and 10-year survival rates of the patients in group A(P>0.05).The treatment result was much better in group A than in group B.