Yb(OTf)_3催化苯乙酮、芳香醛和芳香胺的Mannich反应:三组分“一锅法”合成β-氨基酮衍生物

Yb(OTf)_3 Catalyzed Mannich Reaction of Acetophenone with Aromatic Aldehydes and Aromatic Amines: Three Component One-pot Synthesis of β-Amino Ketone Derivatives

报道了稀土化合物Yb(OTf)3催化的苯乙酮、芳香醛和芳香胺Mannich反应,三组分“一锅法”合成了一系列的β-氨基酮衍生物.该方法操作简单、条件温和、产率较高、催化剂可重复使用,且对环境友好.

The three component “one-pot” Mannich reaction of acetophenone with aromatic aldehydes and aromatic amines catalyzed by Yb(OTf)3 afforded the corresponding β-amino ketone derivatives in high yields under mild conditions. The catalyst Yb(OTf)3 was recycled easily and thus regarded as environmen- tally-friendly catalyst.