氟西汀抗脑卒中后抑郁的观察

Observation of Fluoxetine in Treating Post-stroke Depression

目的:观察氟西汀抗脑卒中后抑郁对神经功能缺损的影响。方法:14 0例患者随机分为2组。治疗组80例,入院后即给予氟西汀0 .4mg口服,晚1次,6～10周为1个疗程。对照组6 0例,入院后口服多虑平2 5mg ,每日1次,其余治疗两组均按脑卒中常规处理。在治疗1周、2周、4周、6周后分别以HAMD量表及ESS量表评定治疗效果。结果:治疗组用药后1周即可显效,而对照组多在2周后显效。两组ESS评分均随HAMD评分下降而下降,两者呈正相关,而治疗组ESS评分较对照组下降明显,有显著性差异(P <0 .0 1)。结论:氟西汀抗脑卒中后抑郁能够改善神经功能缺损症状及患者的预后。

Objective: To explore the effect of nerve function defect of fluoxetine in treating post-stroke depression. Methods: We stochastically devided 140 cases into 2 groups. The treating group of 80 cases were treated with Fluoxetine, oral 0.4mg/d, a course of treatmnt taking a period of 6 to 10 weeks. The control group of 60 cases were treated with Doxepin, 25mg/d. We estimated the curative effect with HAMD TABLE and ESS TABLE after treated 1, 2,4,6 week. Results: The cases in treating group showed obvious effect after one week.The cases in control group showed obvious effect after two weeks. The ESS grade of the two groups declined as HAMD grade declined. Conclusion: Fluoxetine could improve symptoms of nerve function defect and prognosis in treating Post-stroke depression.