靶控输注异丙酚在门诊无痛人流术中的应用研究

Study The Effect of Propofol by Target-controlled Infusion(TCI) in Outpatient Artificial Abortion

目的:评价靶控输注异丙酚在门诊无痛人流手术中的麻醉效果。方法:90例患者随机分为两组即靶控输注组(E组)和手控输注组(H组),每组45例。分别观察和比较两组的麻醉效能、术中呼吸循环的变化、双频脑电指数(BIS)以及术后不良反应等指标。结果:H组的异丙酚总用量显著高于E组(P<0.05),苏醒时间较长,但其诱导时间较短。在注药前、诱导时、术毕时和清醒时两组的心率、血压的差异没有显著性(P>0.05),但H组的动脉血氧饱和度在诱导时显著低于E组(P<0.05)。各时间点上两组的BIS值之间的差异没有统计学意义(P>0.05),但术后H组的恶心头晕等不良反应率高于E组(P<0.05)。结论:靶控输注异丙酚应用于门诊无痛人流手术优于传统的手控输注方法,值得临床推广应用。

Objective: To estimate effect of propofol by target-controlled infusion(TCI) in outpatient artificial abortion. Method: 90 patients were randomly divided into two group: group E(target-controlled infusion) and group H(hand-controlled infusion). Each group is 45 cases. Effectiveness of narcosis, change of respiration and circulation, BIS and side-effect of operation were observed and recorded. Result: Total amount of propofol used in group H was significantly more than group E(P<0.05). The recovery time in group H was more longer but the induced time in group H was more shorter. There were not significantly different in heart rate and blood pressure in operation process between two group(P>0.05). SpO 2 was significantly lower in group H than in group E(P<0.05). There was no significant difference in BIS values between the two groups(P>0.05). There were much more side-effect of operation in group H than in group E(P<0.05). Conclusion: Target-controlled infusion of propofol had a better effect in outpatient artificial abortion than hand-controlled infusion and could be widely applied.