增龄对小鼠心肌氧自由基浓度、超氧化物歧化酶活性及丙二醛含量的影响

Effects of Aging on Myocardial OFR Concentration, SOD Activity and MDA Content of Mice

以心肌氧自由基(OFR)浓度、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量为指标,观察了增龄对心肌自由基反应的影响。结果表明:(1)心肌OFR浓度随增龄上升,至13、17月龄时达到显著水平(P<0.05):(2)心肌SOD活性随增龄下降,至13、17月龄时达到显著水平(P<0.05);(3)心肌MDA含量随增龄而增加,至13、17月龄时增加显著(P<0.05,P<0.01);(4)老年小鼠(17月龄)心肌SOD活性与OFR浓度呈高度显著的负相关关系(P<0.01),而MDA含量与OFR浓度呈显著的正相关关系(P<0.05)。上述结果表明,随增龄心肌自由基损伤性因素(OFR—MDA)增加,而保护性因素(SOD)减弱,这可能是老化心脏在结构、功能、代谢方面发生衰退的原因之一。

Effects of aging on myocardial oxygen free radical (OFR) concentration, superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in mice were studied. Results indicate that with aging the OFR concentration significantly increases ithe SOD activity significantly decreases,both indices being positively correlated ( P <0. 05); the MDA content significantly, and is negatively correlated with the OFR concentration ( P <0. 05). The results suggest that in aged heart, injurious factors of free radicals (OFR-MDA) increase, while protective factor (SOD) weakens, which may be one of the causes that lead to the degenerative changes of aged heart in structure, function and metabolism.