心肌梗塞患者免疫状况与病毒感染的关系

Coxackie B Virus Infection and Immune State of Patients with Myocardial Infarction

对临床诊断为急性心肌梗塞,年龄55～70岁的45例病人的血清进行了可溶性白细胞介素2受体sIL—2R)检测,结果急性心肌梗塞病人sIL-2R平均水平为841.78u/ml,而健康同龄组人平均为410u/ml,两者比较,差异显著(P<0.01).病人血清中循环免疫复合物(CIC)阳性率为46.6％,动态观察的结果急性期显著高于恢复期(P<0.05),恢复期与正常对照无明显差异。用自制的柯萨奇B组病毒(CoxBV)单克隆抗体进行了病毒的检测,其阳性率为29％,同时测定了抗CoxBV的IgM,结果阳性率为28％,均明显高于正常对照(P<0.01)。sIL—2R水平与病毒感染阳性呈平行关系。上述结果提示:部分心肌梗塞的急性发作可能与CoxBV感染有关,而感染与心肌梗塞都可以导致SIL—2R及CIC水平增高。

The relationship between Coxsackie virus B (CoxBV) infection and immune state of the patients with myocardial infarction were studied. The viral antigen in scrum of myocardial infarction patient was detected by the McAb of coxBV 1-6. The positive rates were 29% (13/45); those of specific IgM of coxBV were 46. 6% (21/45). The difference was significant as compared with healthy group ( P <0. 001). The average level of solubility interleukin-2 receptor (sIL-2R) in serum of myocardial infarction patients were 844. 77+364. 66 u/ml. While those in healthy group were 10+97u/ml (P<0. 001); those of circu lating immune complexes were 46. 6% (21/45); those in healthy group were 7. 5% (3/40), (P<0. 001). There was no significant difference between the convalescent and the healthy group. The results showed that the viral infection was an important factor. Virus combined with the antibody led to increasing of CIC.and deposited CIC activate complement,destroyed the epithelium of blood vessel, guided immune absorption further, and eventually embolism was formed.