老年无症状性冠心病患者血清磷酸肌酸激酶及MB同功酶的变化

Changes of Serum CPK and CPK-MB in Aged Patients with Asymptomatic Coronary Artery Disease

测定50例老年无症状性冠心病患者血清磷酸肌酸激酶(CPK)及MB同功酶(CPK—MB)活力,并与同年龄组20例正常人及11例急性心肌梗塞(AMI)患者的结果进行比较。结果发现,无症状性冠心病组与正常对照组比较,CPK值相近,CPK—MB明显升高(P<0.01),CPK—MB/CPK比值明显升高(P<0.01),尽管CPK—MB不如AMI组升高明显,但CPK—MB/CPK比值亦明显高于AMI组(P<0.001)。提示无症状性冠心病有CPK—MB的变化。

Serum creatine phosphokinase (CPK) and isoenzyme MB (CPK-MB) activities were measured in 50 aged patients with asymptomatic coronaryartery disease (CAD) and compared with 20 normal adults and 11 aged patients with acute myocardial infarction (AMI). The results showed that serum CPK activity of asymptomatic CAD patients was similar to that of normal subjects, but CPK-MB was much higher (P<0.001) but lower than AMI patients. Their CPK-MB/CPK ratio was sensitively elevated (P<0. 001). The results suggest that change of CPK-MB is significant in patients with asymptomatic CAD.