米索前列醇配伍催产素预防剖宫产产后出血的临床观察

Clinical Observation of Prevention Postpartum Hemorrhage of Caesarean Birth With Misoprostol and Oxytocin.

目的探讨米索前列醇配伍催产素预防剖宫产产后出血。方法将284例剖宫产者随机分为三组,A 组胎头娩出后肛塞米索前列醇400μg,胎儿娩出后宫体注射催产素20U;B 组胎头娩出后口服米索前列醇400μg,同一时刻肛塞米索前列醇400μg;C 组胎儿娩出后宫体注射催产素20U,同时静脉滴注催产素20U,观察术中及术毕阴道积血量,术后2小时、24小时累积出血量,第三产程时间及副反应。结果 A、B 两组在术中及术毕阴道积血量,术后2小时、24小时出血量较 C 组明显减少;第三产程时间明显缩短,差异有显著性,P<0.05,而 A、B 两组差异无显著性,P>0.05,副反应:B 组较 A、c 两组差异有显著性,P<0.05,而 A、C 两组差异无显著性 P>0.05。结论米索前列醇配伍催产素预防剖宫产产后出血用药安全、有效、快速、持久且副反应小。

Objective To study clinical observation of prevention postpartum hemorrhage of Caesarean birth with Misoprostol and Oxy- tocin. Methods 284 Caesarean birth cases rondomly divided into three groups. Misoprostol 400μg be filled in anus after deliverg of fetal head in group A. Uterus was injected Oxytocin 20u after delivery;Misoprostol 400μg is administered orally and be filled in anus waith Misoprostol 400μg after delivery of fetal head in group B;C group Uterus was injected Oxytocin 20u and intravenous injecting Oxytocin 20u at the same time after de- livery of fetal, observe the amount of vaginal bleeding during the operaton and 2 hours,24hours after opertion,the time of third stage of labor and side effect.Results The amount of vaginal bleeding during the operation and 2hours,24hours,after operation were significantly decreaced than in group C;the time of third stage of labor was significantly short(P<0.05). There was no difference between group A and C(P>0.05) .Conclusion prevention postpartum hemorrhage of Caesarean with Misoprostol and Oxytocin was safe, effective,fast, last with little, side effect.