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PAPP-A与动脉粥样硬化的关系

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摘要 急性冠状动脉综合征的形成机制是斑块不稳定发生破裂并发血栓形成,如何识别不稳定斑块成为目前的研究热点。最新研究显示,在男,女两性体内均存在的妊娠相关血浆蛋白A(PAPP A)。该蛋白酶是金属蛋白酶超家族中的一员,通过激活胰岛素样生长因子,介导动脉粥样硬化形成。PAPP A血清水平增高是局部炎症状态增加的潜在标记因子,有助于早期诊断急性冠状动脉综合征,且与斑块病变的复杂程度和冠状动脉介入术后再狭窄有关,能一定程度上提示预后。
作者 应小盈 王长谦
机构地区 上海第二医科大学附属仁济医院心内科
出处 《国外医学（生理病理科学与临床分册）》 2005年第2期114-117,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 急性冠状动脉综合征 不稳定斑块 妊娠相关血浆蛋白 胰岛素样生长因子
分类号 R543.3 [医药卫生—心血管疾病]
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参考文献18

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国外医学（生理病理科学与临床分册）
2005年 第2期

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