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B淋巴细胞刺激因子与自身免疫性疾病 被引量:3

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摘要 BLyS是肿瘤坏死因子家族新成员,由285个氨基酸组成,为Ⅱ型跨膜蛋白。BLyS可刺激B淋巴细胞增殖、分化和分泌抗体,在机体的体液免疫中发挥重要调节作用。BLyS表达失衡与多种自身免疫性疾病的发生有关。
出处 《国外医学(生理病理科学与临床分册)》 2005年第2期166-169,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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同被引文献54

  • 1周演武,谢菲,周琳,娄加陶,侯彦强,耿红莲,仲人前.人外周血单个核细胞BLyS_(127-285)的克隆、表达和纯化[J].第二军医大学学报,2004,25(12):1335-1337. 被引量:1
  • 2钟华红,杨培增,周红颜,傅涛,黄祥坤,李兵,谢楚芳.γ-干扰素对人眼组织共刺激分子及Fas/FasL分子表达的影响[J].中华眼底病杂志,2006,22(2):117-119. 被引量:3
  • 3李晓良,杨大国,林巧,韩凤星,聂广.1335例慢性乙型肝炎患者血清自身抗体检测分析[J].中西医结合肝病杂志,2006,16(3):162-163. 被引量:22
  • 4Kern C,Cornuel J F,Billard C,Tang R,Rouillard D,Stenou V, et al. Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway[J]. Blood, 2004,103 : 679-688.
  • 5Shu H B, Hu W H,Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens[J]. J Leukoc Biol, 1999,65 : 680-683.
  • 6Moore P A,Belvedere O,Orr A,Pieri K,LaFleur D W,Feng P, et al. BLyS:member of the tumor necrosis factor family and B lymphocyte stimulator[J]. Science, 1999,285 : 260-263.
  • 7Schneider P, Mackay F, Steiner V, Hofmann K, Bodmer J L, Holler N,et al. BAFF,a novel ligand of the tumor necrosis factor family,stimulates B cell growth[J]. J Exp Med, 1999,189 1747-1756.
  • 8Mukhopadhyay A, Ni J, Zhai Y, Yu G L, Aggarwal B B. Identification and characterization of a novel cytokine, THANK,a TNF hom- ologue that activates apoptosis, nuclear factor-kB, and c-Jun NH2- terminal kinase[J]. J Biol Chem, 1999,274:15978-15981.
  • 9Cheema G S, Roschke V, Hilbert D M,Stohl W. Eleveted serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseasas[J]. Arthritis Rheum, 2001,44 : 1313-1319.
  • 10Kalled S L,Ambrose C,Hsu Y M. BAFF:B cell survival factor and emerging therapeutic target for autoimmune disorders[J]. Expert Opin Ther Targets, 2003,7 : 115-123.

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