自体骨骼肌瓣移植于心脏的实验形态学研究

Transposition of skeletal muscle flap in canine heart defect-A mor-phological experimental study

用成年杂种狗带血管神经蒂的背阔肌瓣植入人工缺损的心室壁进行实验观察，结果显示，肌瓣与心肌愈合良好，其间有一明显的疤痕带，有血管通连。近疤痕和缝线部，绝大多数心肌和骨骼肌纤维的形态、结构正常，少数纤维萎缩和纤维化。部分骨骼肌纤维呈心肌样改变，肌原纤维重新排列组合。重组的肌纤维呈心肌样分支，胞核大致位于肌纤维中央。本实验说明自体骨骼肌心肌成形术有可行性。

keletal muscle flap from latissimus dorsi musculus with neurovascular pedicle was trans-ferred to repair the defect in the right or the left ventricular wall of 13 adult dogs. The animalswere sacrificed by overdoLqe anesthetic 3 to 40 weeks postoperatively.Light microscopy showedmorphological healing of the skeletal muscle flap. A cicatrical stripe between the two differentmuscular tissues was identified.which was perforated by tiny blood vessels. The overwhelmingmajority of cardiac and skeletal muscle cells demonstrated normal structures,excepta few showingatrophy and fibrosis.Myocardium-like change was observed in a portion of skeletal muscle cells,as the rearrangement of myofibrils and the formation of myocardium-like branches.