核型异常急性非淋巴细胞白血病111例临床分析

Clinical analysis of 111 cases of acute non-lymphocytic leukemia with pathological karyotypes

目的探讨异常核型的急性非淋巴细胞白血病(ANLL)患者近期疗效。方法R显带法进行核型分析。观察组和对照组分别含111例核型异常和69例核型正常ANLL患者。结果异常核型组完全缓解(CR)率明显低于正常核型组(44.14%对65.22%;P<0.01)。非t(8;21)核型异常组的ANLL患者CR率明显低于正常核型组(28.57%对65.22%;P<0.005)。结论伴复杂核型异常的ANLL疗效较差。

ObjectiveTo explore the therapeutic effect of acute non-lymphocytic leukemia(ANLL) with pathological karyotypes.MethodsAnalyze karyotype with the R-banding technique.The experimental group contained 111 ANLL patients with pathological karyotypes and the control group contained 69 ANLL patients with normal karyotypes.ResultsThe complete remission (CR) rate was apparently lower in the group of pathological karyotypes than that in the group of normal karyotypes (44.14% vs 65.22%;P<0.01).CR rate was apparently lower in the group of non-t (8;21) pathological karyotypes than that in the group of normal karyotypes(28.57% vs 65.22%;P<0.005).ConclusionANLL with complex pathological karyotypes is associated with poor prognosis.