摘要
本文进行了分别由三个厂家生产的法莫替丁在10例正常志愿者中的药代动力学研究。10例正常志愿者交叉口服由温州,青岛及国外生产的2片法莫替丁片(每片20mg),用HPLC法测定法莫替丁的血浆浓度和回收率。研究结果表明:药代动力学符合开放性二室模型。主要药代动力学参数如下:温州组:T_(peak)=2.01±0.34h,C_(max)=166.10±42.96μg·h^(-1)·L^(-1),T_(1/2)β=2.38±0.52h,CLr=12.06±2.18l/h,AUC=920.20±130.00μgh^(-1)·L^(-1);青岛组:T_(peak)=1.87±0.34h,C_(max)=177.08±33.38μg·h^(-1)·L^(-1),T_(1/2)β=2.64±0.69h,CLr=12.07±2.25l/h,AUC=937.23±117.00μg·h^(-1)·L^(-1);国外组:T_(peak)=1.94±0.58h,C_(max)=165.80±38.13μg/1,T_(1/2)β=2.51±0.61h.Clr=12.04±2,421/h,AUC=894.33±130.73μg·h^(-1)·L^(-1)。
The pharmacokinetics of famotidine produced by Wenzhou,Qingdao,foreign pharmaceutica respectively was studied in ten healthy male volunteers after oral administration of two tablets(40mg).Famotidine concentration was determined by HPLC.The plasma level-time curve of famotidine was fitted to two-compartment open model.The pharmacokinetic parameters of famotidine are as follows:Wenzhou(T1):T_(peak)=2.01±0.34h.C_(max)=166. 10±42.96μg/l,AUC=920.20±130,00μg·h ̄(-1)·L ̄(-1),T_(1/2)β=2.38±0.52h,Clr=12.06±2.18 l/h; Qingdao(T2):Tpeak=1.87±0.34h,C_(max)=177.08±33.38 μg/1. AUC=937. 23±117.00μg·h ̄(-1)·L ̄(-1),T1/2β=2. 64±0. 69h.Clr=12.07±2.25 l/h; Foreign(T3):T_(peak)=1.94±0.58h.C_(max)=165.80±38.13 μg/l.AUC=894.33±130.73μg·h ̄(-)·L ̄(-1),T_(1/2)β=2.51±0.61h,Clr=12.04±2.42 l/h;relative bioavailability:F T1/T2(%) = 98.35±10.88%;F T1/T3(%)=102.95±13.35%
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1994年第2期93-97,共5页
The Chinese Journal of Clinical Pharmacology