脑创伤后血清皮质醇测定的临床价值被引量：2

导出

摘要皮质醇(cortisol)是糖皮质激素(glucocorticoids,GCs)的主要激素,是机体对外界刺激产生反应的重要激素,是维持内环境稳态所必需的因子。内源性皮质醇的合成与分泌主要由下丘脑-垂体-肾上腺(hypothalamic - pituitary - adrenal,HPA)轴所调节。不同程度不同类型脑创伤可观察到不同的内源性皮质醇水平变化。严重应激性脑创伤状态下,HPA轴的调节机制可能受到损害,从而导致肾上腺皮质分泌功能的异常。皮质醇作为重要的"应激"激素,测定其外周血液浓度可帮助评价机体脑创伤后的内分泌变化,指导糖皮质激素的应用及估计预后。

作者朱锡德张建宁

机构地区天津医科大学总医院神经外科

出处《国外医学（神经病学．神经外科学分册）》 2005年第2期177-180,共4页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）

分类号 R651.15 [医药卫生—外科学] R562.25 [医药卫生—呼吸系统]

引文网络
相关文献

参考文献20

1Lieberman AL, Oberoi CR, Steven A, et al. Prevalence of neuroendocrlne dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab, 2001, 86(6) :2752 - 2756.
2Dimopoulou I, Tsagarakis S, Douka E, et al. The low - dose corticotropin stimulation test in acute traumatic and non - traumatic brain injury: incidence of hypo - responsiveness and relationship to outcome. Intensive Care Med, 2004, 30(6) : 1216 - 1219.
3Hoen S, Asehnoune K, Brailly - Tabart S, et al. Cortisol response to corticotropin stimulation in trauma patients: influence of hemorrhagic shock. Anesthesiology, 2002, 97(4):807- 813.
4Cemak I, Savic VJ, Lazarov A, et al. Neuroendocrine responses following graded traumatic brain injury in male adults. Brain Inj.1999, 13(12):1005- 1015.
5Dimopoulou I, Tsagarakis S, Anthi A, el al. High prevalence of decreased eortisol reserve in brain - dead potential organ donors. Crit Care Meal, 2003, 31(40) :1113 - 1117.
6Savaridas T, Andrews P, Harris B. Conisol dynamics following acute severe brain injury. Intensive Care Med, 2004, 30(7) : 1479 - 1483.
7Beishuizen A, Thijs LG, Vermes I. Patterns of corticostemid - binding globulin and the free cortisol index during septic shock and muhitrauma.Intensive Care Meal, 2001, 27(10):1584- 1591.
8Hamrahian AH, Oseni TS, Arafah BM. Measurements of Serum Free Corfisol in Critically Ⅲ Patients. N Engl J Med, 2004, 350(16) :1615- 1638.
9Dimopoulou I, Tsagarakis S, Kouyialis AT, et al. Hypothalamic -pituitary- adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin - 6 levels. Crit Care Med, 2004, 32(2):404-408.
10Dimopoulou I, Tsagarakis S, Theodorakopoulou M,et al. Endocrine abnormalities in critical care patients with moderate- to - severe head trauma: incidence, pattern and predisposing factors. Intensive Care Med,2004, 30(6) : 1051 - 1057.

同被引文献14

1江基尧,方乃成,张建平,李维平,徐蔚,朱诚,许文辉,包映辉,王勇,邱永明,罗其中.亚低温治疗重型颅脑损伤前瞻性临床多中心对照研究[J].上海第二医科大学学报,2005,25(3):270-272. 被引量：52
2杨丽.异丙酚在预防人工流产综合征中的作用[J].中国妇幼保健,2005,20(17):2248-2249. 被引量：2
3卢莲芳.心理护理对人工流产综合征的预防作用[J].实用医技杂志,2006,13(7):1168-1169. 被引量：22
4白红梅,解珂,崔苏扬.七氟醚吸入用于人工流产术对血浆肾素、血管紧张素Ⅰ、血管紧张素Ⅱ和皮质醇的影响[J].临床麻醉学杂志,2007,23(3):196-197. 被引量：4
5宋宇,赵洪洋.亚低温对继发性脑损伤保护作用的研究进展[J].第四军医大学学报,2007,28(10):954-956. 被引量：3
6Lieberman AL, Oberoi CR, Steven A, et al. Prevalence of neuroendocrine dysfunc- tion in patients recovering from traumatic brain injury. J Clin Endocrinol Metab, 2001,86(6) :2752 -2756.
7Agha A, Rogers B, Mylotte D, et al. Neu- roendocrine dysfunction in the acute phase of traumatic brain injury. Clin Endocrinol (Oxf), 2004, 60(5) :584 -591.
8Savaridas T, Andrews PJ, Harris B. Cor- tisol dynamics following acute severe brain injury. Intensive Care Med, 2004, 30 (7) : 1479 - 1483.
9Dadlez EM, Andrews WL. Post-abortion syndrome : creating an af- fliction[J]. Bioethics, 2010,24(9) : 445-452.
10Zoccola PM, Dickerson SS. Assessing the relationship between ru- mination and cortisol : a review[ J ]. J Psychosom Res ,2012,73 ( 1 ) :1-9.