1,8-二(2-甲基-1,3,4-噁二唑)辛烷的合成

Synthesis of 1,8-Bis(2-Methyl-1,3,4-Oxdiazole)Octanes

以癸二酸为原料,经过酯化、肼解及乙酰化3步反应合成N,N’-二乙酰基癸二酰二肼;再在N,N’-二乙酰基癸二酰二肼与三氯氧磷的摩尔比为1:10,三氯氧磷5mL,POCl3与CH3CN的体积比为1:8,在此条件下反应4h,水解72h,得到1,8-二(2-甲基-1,3,4-口恶二唑)辛烷,产率为82%.

In this paper,N,N’-diacelysebacic acid dihydiazide has been synthesized by esterifying,dehydrazine,acetyzing with sebacic acid.Then with mol_(N,N’-diacelysebacic acid dihydiazide) :mol_(Phosphoryl chride)=1:10(mol:mol),Phosphoryl chride 5mL,V_(Phosphoryl) chride :mol_(Acetonitrile)=1:5,reflux Four hours,hydrolysis seventy-two hours .1,8-Bis(2-Methyl-1,3,4-Oxdiazole)Octanes was synthesized and the yield was 82%.