妊娠滋养细胞疾病的发病机制研究进展

Progress in research on molecular pathogenesis of gestational trophoblastic diseases

人类滋养细胞是有异于体细胞的特殊细胞,具有独特的分化特点和生物学特性。妊娠滋养细胞疾病的发生、发展更是多因素参与、极其复杂的病理过程。现代医学研究对该疾病的发生机理有进一步的认识。现就滋养细胞分化和分子生物学特点进行综述。

Gestational trophoblasts are special cells different from somatic cells, which h ave specific biological and differentiational characteristics. Simila r to other h uman tumours, occurrance and development of GTD involve multifactorial path ological process and multipl e genetic alterations including activation of oncogenes, inactivation of tumour suppressor genes. In addition, expression of telomerase activity and matrix meta lloproteinases have also been found in GTD. Recent studies have focused on the molecular mechanisms of trophoblastic function and pathogenesis of gest ational trophoblastic diseases. This article reviewed advancements in research o n these issues.