子宫自然杀伤细胞与滋养细胞间的识别及作用

The role and mutual recognition of uterine NK cells and trophoblasts

子宫自然杀伤细胞参与生殖免疫。最新的研究结果显示子宫自然杀伤细胞与外周血淋巴相比有一定独特性,其能够识别包括人类白细胞抗原Ⅰ类分子在内的多种由滋养细胞表达及分泌的物质。这些物质与受体结合后可能起调控子宫自然杀伤细胞活性的作用,也可能调节其细胞因子的分泌,对滋养细胞浸润,胎盘血管重铸起重要作用。

Uterine NK cells (uNK cells )take part in the reproductive immunology. The lated research showed that uNK cells have some characteristics different from the PBMC. They could recognize many products including human leuko cyte antigen classⅠ(HLA-Ⅰ) expressed and secreted by trophoblasts. When thes e products bind to their receptors,they could play a role in controlling activ ity of uNK cells or secretion of cytokines. These are imp ortant for invasion of trophoblasts and rebuilt of uteroplacental vessels.