肝硬化患者凝血功能检测的意义

The Clinical Significance of Detectingcoagulation Function Parameters in Hepatocirrhosis Patients

目的:探讨肝硬化患者血浆凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原及D-二聚体等凝血功能指标的变化及其意义。方法:确诊的72例不同原因引起的肝硬化患者作为试验组,4 9例健康体检者作为正常对照组。采用美国ACL -Futura全自动凝血仪测定PT、APTT、Fbg及D- 二聚体含量。结果:与正常对照组比较,肝硬化组PT和APTT明显延长(P <0 .0 1) ,Fbg明显减少(P <0 .0 5 ) ,D -二聚体量明显升高(P <0 .0 1) ;且肝硬化患者的Fbg和D- 二聚体含量的异常率明显高于其他两项指标(P <0 .0 5 )。结论:对肝硬化患者进行PT、APTT、Fbg及D -二聚体等凝血功能指标的检测,有助于准确地评价肝硬化患者肝脏损害的严重程度及其预后的判定,并对预防肝硬化患者是否有出血倾向等并发症的发生,具有重要的医学意义。

Objective To investigate the variation and clinical significance of several coagulation function parameters,fuch as prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fbg)and D-dimer in hepatocirrhosis patients. Methods There are 72 hepatocirrhosis patients,who have been diagnosed,as test group,while other 49 healthy people as control group.Through automatic coagulometer of Amehcan ACL-Futura Corporation,we measure the parameters mentioned above.Results In comparison with control group,the Value of PT、APTT and D-dimer are significantly higher (P<0.01)in patient group respectively,But the Value of Fbg of patient group are significantly lower than control group(P<0.05);the abnormal ratio of the value of Fbg and D-dimer are Significantly higher(P<0.05)than the other two parameters.Conclusion The detections of these coagulation function parameters,such as PT,APTT,Fbg and D-dimer,have important clinical significance.And they are useful for evaluating the severity of the liver and estimatingprogonosis and preventing the occurrence of syndrome in hepatocirrhosis pahents.