美多心安逆转高血压病患者遗传性心脏改变

GENETIC CARDIAC DISORDERS IN PROGENY OF HYPERTENSIVES CAN BE REVERSED BY β1-BLOKERS METOPROLOL

以Ｍ型心超声检测５０名无高血压家族史的年轻后代得心脏各参数正常值。约在３０％有高血压家族史的年轻后代筛选出具遗传性左心结构及（或）功能异常的，共４９名分成以β１受体阻滞剂美多心安干预的２６名和对照组２３名比较观察。发现经干预９月后９０％对象的心脏改变被逆转；而对照组无变化，提示心超声图可作为在高血压病患者子女检出其遗传性心脏改变的高血压易患者方法；β１受体阻滞剂能逆转这种变化，从而通过早期消除该病理基础而有益于Ⅰ级预防高血压病的发生。

Normal cardiac parameters of echocardiographgy were derived in 50 young offsprings without family history of hypertension。49 adolescents with genetic structural and/or functional cardiac disorders,about 30%of the progeny of hypertensives,were detected by screening.Ofthem 26 sub-jects were allocated to intervention group and treated with β1-bloker metoprolol,and 23 subjects to control group. The two groups were followed up in parallel for 9 months. Re- sults showed that the genetic cardiac disorders were re-versed in 90% of the formet while not changed in the lat- ter. It suggests that the echocardiography examination can be a valuable tools for screening of those who are progeny of hypertensives and susceptive to develop genetic cardiac disorders,and theβ1-bloker can reverse these disorders at early stage.It will contribute much to the primary preven-tion of essential hypertension.