广州市海珠区肺癌病例－对照研究

A CASE-CONTROL STUDY ON LUNG CANCER IN GUANGZHOU

本文报道了１７４例肺癌病例按１：２配对调查的结果。吸烟者患肺癌的ＯＲ为２．２４，其中男性ＯＲ为２．４７、女性ＯＲ为２．０５。肺癌组与对照组的ＯＲ差别显著，其ＯＲ随吸烟量的增加而增加，存在剂量反应关系，尤其是大量吸烟（≥２０支／天）与＜２０支／天及不吸烟者之间的差别更显著。开始吸烟年龄组越小者，患肺癌的ＯＲ越大，吸烟年限越长其ＯＲ越大，肺癌与对照的比例也越大，尤其是吸烟年限≥３１年与〈３０年及不吸烟者比较，均有显著差别。环境污染因素中，肺癌患者住地环境空气中ＮＯ２、ＳＯ２的浓度比健康人群高，与生活用煤柴无关。但与通风是否良好有关，说明吸烟是得肺癌的主要因素，环境亦起重要作用。

This papper reports the results of a case-control studyon 174 cases of lung cancer matched with controls in a ratloof 1 to 2.OR for smokers was2.34,for male smokers 2.47,for female smokers 2.05 The difference in OR betweensmokers and mon-smokers was signiflcant.OR increasedwith a Increasing the amount of Clgarette smoking,and thedose-response relationship exlsted between smoking andlung cancer.The difference in OR was quite significant be-tween smokers who smoked>20 cigarettes dally and thoseless 20 cigarettes dally. The age at onset of smoking theyounger and the duration of smoking the longer.the OR for1ung concer the greater. As compared to non-smokers andsmokers who smoked for≤30 years ,OR in smokers for≥31 years was significantly higher.The concentratlons ofNO2and SO2 in air around lung cancer patlents' residencewere higher than that of healthy controls. The degree of airpollution was not associated with burning coal and woodbut ventilation。The findings suggest that smoking is a ma-jor risk factors for lung cancer,and air pollution also exertsan important role.