摘要
为探讨大肠癌发病的高危因子，对大肠癌高发区嘉善县进行了大肠癌病例－对照研究。经条件Ｌｏ－ｇｉｓｔｉｃ回归单因素分析结果发现计会环境因素中的高危因子有：精神刺激史、文盲以及吃红烧鱼者等，与大肠癌相关的症侯有：慢性腹泻、便秘、粘液血便、服导泻药史等；其中发现保护因素有：哮喘史及饮酒。以上各因素经条件Ｌｏｇｉｓｔｉｃ回归模型多因素分析调整后进入模型的有：粘液血便（ＯＲ＝３７．０２，９５％ＣＬ１３．１４～１０４．３）、慢性腹泻（ＯＲ＝５．１８６，９５％ＣＬ２．１０１～１２．８０）、饮酒（ＯＲ＝０．３５５，９５％ＣＬ０．１５９～０．７９５）。此外还发现有家族大肠癌史者大肠癌发病年龄提前，有家族肿瘤史的女性直肠癌相对危险增高，遗传因素在大肠癌发病过程中起一定的作用。
In order to make a further study on the risk factors ofcolorectal cancer,a population-based
case-control studywas conducted in Jiashan county of Zhejiang province fromDec.1992 to Jan.
199The control study included 286 caseswith colorcctal cancer.Singe factor analysis showed
thatchronic diarrhea,mucous bloody stool,constipation,admin-istration of cathartics ,history of
psychic trauma, low educa-tional level and eating fried fish with soy sauce were associ-ated
with colorectal cancer. There was no correlation withasthma and drinking.The multivariate
conditional logisticregression analysis demonsttated that colorectal cancer wasrelated to
mucous bloody stool(OR = 37.02 ,95%CL 13.14-104.3),chronic diarrhea(OR=5.286,95%CL
2.101-12.80)and drinking(OR=0.355,95%CL 0.159-0.795).This study also revealed that the onset
age of colorec-tal cancer was earlier in patients having a farnily historywith colorectal cancer
and the odd ratio of colon cancer inwomen with family cancer history was
3.00(95%CL1.12-7.22).It suggested that genetic factor might also play acertain role in the
occurrence of colorectal cancer.
出处
《中国慢性病预防与控制》
CAS
1994年第3期122-123,126,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
大肠肿瘤
流行病学
病例对照研究
Colorectal cancer Risk factor Case-conttol study
Conditional logistic regression analysis
