摘要
[目的]探讨化疗所致恶心呕吐与抑郁症的关系及临床应用氟西汀进行干预的可行性。[方法]采用随机、前瞻性的自身对照研究,共52例患者入组,34例进行治疗组,接受氟西汀20mg/天,连用14天或以上;对照组18例,未予氟西汀治疗。[结果]化疗所致恶心呕吐的严重程度与抑郁密切相关(Rs=0.225,F=14.505,P=0.000);恶心呕吐情况,治疗组稳定和有效30例(88.2%),对照组11例(61.1%,χ2=5.191,P=0.023)。氟西汀的副作用少且可耐受。[结论]氟西汀能有效降低恶心呕吐的严重程度,值得临床进一步研究。
To explore the relationship between nausea, vomiting and depression in cancer patients and to investigate the feasibility of fluoxetine hydrochloride intervention. Fifty-five cases with cancer were assigned into this prospective rendomized clinical study, 34 cases of them were assigned to treatment group, accepting fluoxetine hydrochloride 20mg per day for more than 14 days while 18 cases (control group) with no fluoxetine hydrochloride. The degree of nausea and vomiting caused by chemotherapy had a positive correlation with depression (Rs=0.225, F=14.505, P=0.000). The response rate was 88.2% in treatment group, and in 61.1% control group (χ2=5.191, P=0.023). The toxicity of fluoxetine hydrochloride was mild and tolerable. Fluoxetine hydrochloride can effectively reduce the degree of chemotherapy-inducal nausea and vomiting in cancer patients. It needs further clinical trial.
出处
《肿瘤学杂志》
CAS
2005年第1期55-57,共3页
Journal of Chinese Oncology
关键词
肿瘤
药物疗法
氟两汀
恶心
呕吐
neoplasms
drug therapy
fluoxetine hydrochloride
nausea
vomiting
