X综合征患者超敏C反应蛋白及颈动脉内膜中膜厚度的观察

Study on hypersensitive C-reactive protein level and imtimal-media thickness of carotid arteries in the patients with X syndrome

目的观察X综合征患者血清超敏C反应蛋白水平及颈动脉内膜中膜厚度,探讨X综合征和动脉粥样硬化之间的关系。方法选取两组受试对象: 21例X综合征患者, 20例正常对照组。测定X综合征患者和正常对照组血清超敏C反应蛋白(hs CRP)水平;采用高分辨力超声多普勒分别测定X综合征患者和正常对照组颈动脉内膜中膜厚度(IMT)。将以上结果进行统计学分析。结果X综合征患者的hs CRP水平明显高于对照组,颈动脉IMT也较正常对照组明显增厚。结论在冠状动脉内皮功能紊乱致冠状动脉舒张储备不良和异常收缩的基础上,动脉粥样硬化可能也参与了X综合征的发病过程。

Objective To investigate the difference of the serum hypersensitive C-reactive protein level and imtimal-media thickness of carotid arteries in the patients with X syndrome and normal subjects. Methods Twenty-one patients with X syndrome and twenty healthy controls were included in the study. The serum hypersensitive C-reactive protein level was assayed in 21 patients with X syndrome and in 20 healthy volunteers; and the imtimal-media thickness of carotid arteries in the two groups was measured with high-resolution ratio ultrasound. Results The serum hypersensitive C-reactive protein level of patients with X syndrome were significantly higher than those in the healthy volunteers. Imtimal-media thickness of carotid arteries was significantly lower in patients with X syndrome than that in the healthy volunteers. Conclusion Atherosclerosis might be correlated with pathogenesis of X syndrome.