摘要
采用荧光抗体间接法（ＩＦＡ）对３９例慢性丙型肝炎患者血清进行了自身抗体检测。结果显示慢活肝（ＣＡＨ）抗核抗体（ＡＮＡ）和抗平滑肌抗体（ＳＭＡ）检出率均高于健康人（Ｐ＜０．０５，Ｐ＜０．０１）。自身抗体阳性的慢性丙型肝炎患者血清转氨酶显著高于自身抗体阴性患者。因此认为自身免疫可能是丙型肝炎病毒（ＨＣＶ）慢性感染后肝组织损伤的重要因素。
utoantibodies were measured in 39
patients with chronic hepatitis C by using indirect
im-munofluorescence,We found that the detecting rates of ANA and SMA
in CAH were higherthan those in donors(P<0.05,P<0.01).Patients with
autoantibodies were more likely than patientswithout autoantibodies
to be symptomatic(57.1%vs 22.2%)and have higher ALT(mean=424 vs
215U/L)and Globulins (mean=4.1vs 2.4g/dl). We suggested that the
autoimmune was an important factor in hepato-cyte injuries in
patients with chronic hepatitis C.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第1期59-60,共2页
Chinese Journal of Immunology
关键词
丙型肝炎
抗体
免疫荧光法
Chonic hepatitis C
Autoantibodies Indirect immunofluorescence.
