补肾中药对SRBC免疫大鼠脑和脾脏组织中神经递质含量的影响

THE EFFECT OF KIDNEY-BENEFITING CHINESE HERBELMEDICINE ON NEUROTRANSMITTERS IN BRAIN AND SPLEENAFTER IMMUNIZED RATS USING SRBC

用ＨＰＬＣ－ＥＣＤ测定了被绵羊红血球（ＳＲＢＣ）免疫后大鼠脑和脾脏组织中ＮＥ、Ｅ、５－ＨＴＰ、５－ＨＴ、５－ＨＩＡＡ、５－ＨＤＡ、ＤＡ和ＨＶＡ八种神经递质（Ｎｅｕｒｏ）含量，观察到被ＳＲＢＣ免疫后的大鼠胞和脾组织的Ｎｅｕｒｏ含量大多明显降低，甚至测不到．西药、中药尤其是补肾中药对正常大鼠脑和脾脏Ｎｅｕｒｏ均有明显促进作用，对被ＳＲＢＣ免疫后的大鼠脑和脾脏中的Ｎｅｕｒｏ含量大部有改善作用，其中补肾中药作用最好，使降低了的Ｎｅｕｒｏ含量几乎恢复正常。

t was delected in brain and spleen after immunized rats using SRBC to eight neurotrans-mitters(NT) including NE(Noradrenaline),E(Epinphrine),5-HT(5-Hydroxytrptamine),5-HTp(5-Hydr oxytrptophane),5-HIAA(5-Hydroxyindoleacetic),5-HDA(5-Hydroxydopamine) ,DA(Dopamine)and HVA(Homovanillicacid)with HPLC-ECD. It observed that neurotrans-mitters were decreased obviously in brain and spleen after immunized rats using SRBC. It did notso much as detected this. The drugs including west medicine,chinese herbel medicine and kid-ney-benefiting chinese herbel medicine(KBCHM)have promoted obviously on eurotransmittersfor normal rat’s brain and spleen as well as it also have benefited on neurotransmitters in brainand spleen for after immunized rats using SRBC, But the effection of KBCHM was best.It wasmade decreased neurotransmitter to returned to normal level.