摘要
在观察乙型肝炎特异性病毒抗原诱导乙肝患者淋巴细胞产生IL-6以及IL-6在乙肝自身免疫发生中的作用发现:HBcAg可诱导患者产生IL-6,而HBsAg则无此作用;IL-6可协同HBcAg等促进乙肝患者自身抗体─—抗LSP的形成,而且患者高活性水平IL-6与血清中抗LSP抗体的滴应有一定相关性。IL-6在体外可增强患者非特异性IgG形成,但不能促进抗HBs形成。
o clarify the effect of
Interleukine 6(IL-6)on pathogenesis of viral hepatitis B. The
IL-6activity and its effect on production of autoimmune antibody in
patients with HBV infectionswere carried out in our Lab.The results
showed that only HBcAg,not HBsAg was ablt to induceIL-6 in patients
with CHA and FH.The result also indicated that IL-6 could promot
patients toproduce anti-LSP and IgG,but not anti-HBs.There was a
ccorlation between IL-6 and anti-LSPin patients.It was suggested that
the abnormal IL-6 production of patients with HBV infectionsmay play
an important role in autoimmune reaction and aberration or
immunregulation of HBVinfections.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第3期188-190,共3页
Chinese Journal of Immunology
基金
国家自然科学基金