摘要
在观察乙型肝炎特异性病毒抗原诱导乙肝患者淋巴细胞产生ＩＬ－６以及ＩＬ－６在乙肝自身免疫发生中的作用发现：ＨＢｃＡｇ可诱导患者产生ＩＬ－６，而ＨＢｓＡｇ则无此作用；ＩＬ－６可协同ＨＢｃＡｇ等促进乙肝患者自身抗体─—抗ＬＳＰ的形成，而且患者高活性水平ＩＬ－６与血清中抗ＬＳＰ抗体的滴应有一定相关性。ＩＬ－６在体外可增强患者非特异性ＩｇＧ形成，但不能促进抗ＨＢｓ形成。
o clarify the effect of
Interleukine 6(IL-6)on pathogenesis of viral hepatitis B. The
IL-6activity and its effect on production of autoimmune antibody in
patients with HBV infectionswere carried out in our Lab.The results
showed that only HBcAg,not HBsAg was ablt to induceIL-6 in patients
with CHA and FH.The result also indicated that IL-6 could promot
patients toproduce anti-LSP and IgG,but not anti-HBs.There was a
ccorlation between IL-6 and anti-LSPin patients.It was suggested that
the abnormal IL-6 production of patients with HBV infectionsmay play
an important role in autoimmune reaction and aberration or
immunregulation of HBVinfections.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第3期188-190,共3页
Chinese Journal of Immunology
基金
国家自然科学基金
