超敏C反应蛋白在急性缺血性卒中中的应用

The role of high-sensitivity C-reactive protein (hs-CRP) levels in acute ischaemic stroke

目的探讨急性缺血性卒中与血清超敏C反应蛋白(hs蛳CRP)的关系。方法对155例经头颅CT或MRI证实的急性缺血性卒中患者于发病3d内采用比浊法测定hs蛳CRP,根据hs蛳CRP的结果分组。结果梗死病灶大的患者血清hs蛳CRP水平明显高于梗死病灶比较小的患者(P<0.05),有脑卒中病史的患者血清hs蛳CRP的水平高于无脑卒中病史的患者(P<0.05)。结论在卒中和动脉硬化的病因学中炎症反应起重要作用,在卒中的处理中还需要进一步采取干预炎症反应的治疗。

Objective Recent studies described an association between elevated levels of high-sensitivity C-reactive protein (hs-CRP) and outcome after ischemic stroke. This study investigated how hs-CRP levels changed in response to neural damage occurred after ischaemia. Methods We analyzed the relationship between serum hs-CRP and acute ischemic stroke in 155 subjects (mean age 65.2 +/- 11.1 years; 64 females and 91 males). Computed tomography or nuclear magnetic resonance imaging of the brain was performed.The serum high- sensitivity C-reactive protein (hs-CRP) concentration was determined nephelometrically in patients with acute thrombotic stroke (< 3d after onset) and patients were subdivided based on the hs-CRP level. Results Serum levels of hs-CRP were significantly higher in patients with large area stroke and history of stroke than in those with small (P < 0.05) and no history of stroke (P < 0.05). Conclusions These findings are consistent with current hypotheses regarding the inflammation or infection as important etiological risks for atherosclerosis and stroke. The new therapeutic interventions now is available to reduce the inflammatory response.