灌注化疗前后P_(53)、bcl-2和血管内皮生长因子在浸润性膀胱肿瘤中的表达

Expression of P_(53)bcl-2 and VEGF in patient with invasive bladder tumor before and after Intra-arterial chemotherapy

目的探讨髂内动脉灌注化疗前后P53、bcl-2、血管内皮生长因子(VEGF)在浸润性膀胱肿瘤组织中表达的意义。方法采用免疫组化法对8例浸润性膀胱肿瘤患者动脉灌注化疗前后血清中的P53、bcl-2、VEGF进行检测。结果灌注前P53的表达率为50%(+～++),bcl-2的表达率为50%(+～+++),VEGF的表达率为50%(+～++);灌注后P53的表达率为50%(+～++),bcl-2为阴性,VEGF的表达率为50%(+)。结论灌注化疗能降低肿瘤标记物的表达,检测P53、bcl-2、VEGF对肿瘤治疗的有效性和预后判断有重要意义。

Objective To investigate the significance of expression of P53?bcl-2 and VEGF in patient with invasive bladder tumor before and after Intra-arterial chemotherapy. Methods 8 cases of bladder tumors were detected by immunohitochemistry technique on P53?bcl-2 and VEGF before and after Intra-arterial chemotherapy. Results Before Intra-arterial chemotherapy, the expression rate of P53, bcl-2 and VEGF were all 50%; after Intra-arterial chemotherapy, P53 was 50%, bcl-2 was negative and VEGF was 50%. Conclusions Intra-arterial chemotherapy can reduce the expression of tumor markers, it may play an important role in effective therapy of invasive bladder cancer and the evaluation of prognosis.