右归饮对大鼠下丘脑－垂体－肾上腺－胸腺轴抑制模型的影响

THE REGULATION OF YG ON THE HYPOTHALAMIC-PITU-ITARY-ADRENAL THYMUS AXIS OF RATS INHIBITED BY COR-TICOSTERONE

用皮质酮（ＣｏｒｔｉｃｏｓｔｅｒｏｎｅＣＯＲＴ）造成大鼠下丘脑－垂体－肾上腺－胸腺轴（ＨＰＡＴ）抑制模型，观察右归饮的调节作用。结果表明：模型大鼠ＨＰＡＴ轴从功能到形态出现抑制，血浆ＣＯＲＴ、ＡＣＴＨ降低，脾细胞减少，淋巴细胞增殖反应减弱；室旁核ＣＲＦ神经元及正中隆起ＣＲＦ神经纤维、垂体前叶ＡＣＴＨ细胞等免疫组化染色明显变淡，数量变少，肾上腺、胸腺萎缩。２００％右归饮灌胃（１０ｇ／ｋｇ体重）可以有效保护ＣＯＲＴ对ＨＰＡＴ轴的抑制。文章对其可能作用机理作了初步分析。

n experimental model of the Hypothalamic-Pituitary-Adrenal-Thymus(HPAT)axis ofrats inhibited by corticosterone(CORT) was established and then we observed the regulation ofYOU GUI YIN(YG)on the HPATaxis inhibited by CORT. the results showed that both thefunction and the morphology of the HPAT axis were inhibited significantly.The contents ofCORT and ACTH in plasma decreased,the lymphocytes in spleen decreased and its proliferativereaction diminished. Analysed by immunohistochemistry,we observed that the numbers of CRFneurocytes in paravei1tricular nucleus.CRF neurofibril in median eminence and anterior pituitaryACTH secreatocytes decreased,and all of their immunohistochemistry staining became fadercompared with the control group. We also observed that there were atrophy in adrenal and thy-mus. After administered 200%YG(10g/kg)to the experiment group,it was found that YG an-tagonised the inhibition of the HPAT axis caused by CORT effectively. The probable mecha-nism of YG have been discussed in this paper.