肾病综合征血清游离甲状腺素与肿瘤坏死因子、清蛋白及尿蛋白的关系

Clinical Study of Relationship between Free Thyroxine Levels and Serum Tumor Necrosis Factor, Albumin, Urinary Protein in Children with Nephrotic Syndrome

目的探讨肾病综合征(NS)患儿血清游离甲状腺素(FT3、FT4)变化及其与肿瘤坏死因子(TNF)、清蛋白(Alb)及尿蛋白的关系。方法检测活动期NS 60例患儿血清FT3、FT4、TNF、Alb及尿蛋白,25例正常儿童作为对照组。结果肾病组血清FT3、FT4降低,与正常对照组比较有显著性差异(P<0 01),NS组血FT3、FT4与Alb呈正相关,与TNF,尿蛋白呈负相关。结论NS患儿活动期存在甲状腺功能低下,为小剂量甲状腺素(TH)佐治NS提供理论依据。

Objective To study the changes of serum free triiodothyronine (FT3), free tetraiodothyronine (FT4) and the relation between free thyroxine levels and serum tumor necrosis factor (TNK), albumin (ALB), urinary protein in children with primary nephrotic syndrome(PNS). Methods There were sixty children who were suffered from nephrotic syndrome in study group Serum FT3,FT4,TNF, Alb and urinary protein were detected. In the meantime compared with 25 health,cases. Results The levels of FT3, FT4 of the children who were suffered from nephrotic syndrome were lower. The difference between nephrotic syndrome and health cases were significantly (P<0.01). The levels of serum FT3,FT4 were related consistent with serum albumin concentration and related negatively line with TNF and the urinary protein. Conclusions The function of the thyroid gland of the children who are suffered from nephrotic syndrome in active phase is lower. It can supply theory evidence for the children who are suffered from nephrotic syndrome to be treated with little dose of thyroxme.