谷氨酸对多发性抽动症发病的影响

Pathogenic Role of Glutamic Acid in Tourette's Syndrome

目的探讨谷氨酸对儿童多发性抽动症(TS)发病可能的影响。方法侧脑室注射谷氨酸,用TS动物模型评分方法观察动物的刻板行为;利用积蓄中毒方法,喂饲大鼠谷氨酸,并观察1个月后行为变化。结果1.与对照组比较,侧脑室注射100μg和200μg谷氨酸,均可诱导大鼠出现明显的TS样刻板行为(P<0.05)。2.在饮水中添加谷氨酸(40mg/kg)1个月后可诱导新生(P<0.001)和1月龄大鼠TS样刻板行为明显增加(P<0.01)。结论谷氨酸参与大鼠TS样刻板行为的发生。

Objective To investigate the effect of glutamic acid (monosodium glutamate,MSG) on Tourette's syndrome (TS). Methods These rats were divided into 2 groups: one group with acute intracerebroventricularly injection (ICV) of MSG or artificial cerebrospinal fluid (CSF), and another group with chronic administration of MSG in a dose of 40 mg/kg in drinking water everyday. Observers who were blind to the two- part subjects assessed the scores of TS- like stereotyped locomotion. Results 1. These groups of 100 ?g or 200 ?g glutamic acid may induce significant TS - like stereotyped locomotion ( P < 0.05); 2. There was a significant increase of TS - like stereotyped locomotion after the administration of MSG for a month in every day's water in neonatal rats (P < 0.001)and one-month rats(P<0.01). Conclusion Glutamic acid or MSG may involve in the pathogenic mechanisms of TS- like stereotyped locomotion in rats.