期刊文献+

基质金属蛋白酶/基质金属蛋白酶组织抑制因子与糖尿病肾病的研究进展 被引量:12

Progress of MMPs/TIMPs and Diabetic Nephropathy
下载PDF
导出
摘要 糖尿病肾病(DN)是糖尿病(DM)的主要并发症之一,基质金属蛋白酶(MMPs)及其特异性抑制物基质金属蛋白酶组织抑制因子(TIMPs)在DN发病机制中起重要作用,本文综述MMPs/TIMPs在DN中的变化机制及其临床意义。
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2005年第5期475-477,共3页 Journal of Applied Clinical Pediatrics
基金 山东省自然科学基金项目资助(Y2002C35)
  • 相关文献

参考文献20

  • 1段文澜,方京冲,杨秀芳,史虹莉,朱禧星,陈文平,张志刚.基质金属蛋白酶在类似人类2型糖尿病大鼠肾病中的研究[J].中国糖尿病杂志,2001,9(5):290-294. 被引量:15
  • 2钱莉玲,常立文,容志惠,张谦慎.维甲酸治疗新生大鼠高氧肺发育受抑对肺组织基质金属蛋白酶及其组织抑制剂表达的影响[J].实用儿科临床杂志,2002,17(6):602-604. 被引量:12
  • 3李艳,王伟铭,陈楠.IGF-1对人成纤维细胞基质降解酶及其抑制物表达的影响[J].上海医学,2001,24(2):78-80. 被引量:10
  • 4Wu K, Setty S, Mauer SM, et al. Altered kidney matrix gene expression in early stages of experimental diabetes [J]. Acta Anat (Basel), 1997,158(3): 155 - 165.
  • 5Suzuki D, Miyazaki M, J inde K, et al. In situ hybridization studies of matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-I and type Ⅳ collagen in diabetic nephropathy[J]. Kidney Int, 1997,52(1):111-119.
  • 6Mclennan SV, Zilkens RR, Yue DK, et al. Reduction of leucocyte proteolytic enzyme activity in diabetic patients with microalbuminuria and proteinuria: its possible role in diabetic nephropathy[J]. Diabet Mned, 1996,13(2): 145 - 149.
  • 7McLennan SV,Yue DK,Turtle JR. Effect of glucose on matrix metalloproteinase activity in mesangial cells[J]. Nephronology, 1998,79(3) :293 - 298.
  • 8McLennan SV, Martell SYK, Yue DK. High glucose concentration inhibits the expression of membrane type metalloproteinase by mesangial cells: possible role in mesangium accumulation [J]. Diabetologia, 2000,43: 642 - 648.
  • 9Shankland SJ, Scholey JW, Ly H, et al. Expression of transforming growth factor- beta 1 during diabetic renal hypertrophy[J]. Kidney Int, 1994,46 (2): 430 - 442.
  • 10Singh R, Song RH, Alavi N, et al. High glucose decreases matrix metalloproteinase-2 activity in rat mesangial cells via transforming growth factor-beta1 [J]. Exp Nephrol,2001,9(4) :249- 257.

二级参考文献30

  • 1[1]Saugstad OD. Brochopulmonary dysplasia and oxidative stress: are we closer to an understanding of the pathogenesis of BPD[J] ? Acta Pae diatr, 1997;86(12): 1277~ 1282
  • 2[2]Malpel S, Mendelsohn C, Cardoso WV. Regulation of retinoic acid sig naling during lung morphogenesis[J]. Development, 2000; 127 ( 14 ): 3057 ~ 3067
  • 3[3]Pierce RA, Shipley MJ. Retinoid-enhanced alveolization: identifying relevant downstream targets[J ]. Am J Respir Cell Mol Biol, 2000; 23 (2) :137~141
  • 4[4]Chailley-Heu B, Chelly N, Lelievre-Pegorier M, et al . Mild vitanin A deficiency delays fetal lung maturation in the rat[J]. Am J RespirCell Mol Biol, 1999;21(1) :89~96
  • 5[5]Massaro D, Massaro GD. Pulmonary alveous formation: critical pe riod,retinoid regulation and plasticity [ J ]. Novartis Found Symp, 2001 ;234:229~236;236~241
  • 6[6]Veness-Meehan KA, Bottone FG Jr, Stiles AD. Effects of retinoic acid on airspace development and lung collagen in hyperoxia-exposed new bom rats[ J ]. Pediatr Res, 2000; 48 (4): 434~ 444
  • 7[7]Nabeyrat E, Corroyer S, Besnard V, et al . Retinoic acid protects a gainst hyperoxia-mediated cell-cycle arrest of lung alveolar epithelialcells by preserving late Gl cyclin activities[J ]. Am J Respir Cell Mol Boil,2001 ;25(4) :507~514
  • 8[8]Pardo A, Barrios R, Maldonado V, et al . Gelatinases A and B are upregulated in rat lungs by subacute hyperoxia pathogenetic implications[J]. Am J Pathol, 1998; 153 (3) :833~ 844
  • 9[9]Radomski A, Sawicki G, Olson DM, et al . The role of nitric oxide and metalloproteinases in the pathogenesis of hyperoxia-induced lung injury in neonatal rats[J]. Br J Pharmcol, 1998; 125 (7): 1455 ~ 1462
  • 10[10]Frankenberger M, Hauck RW, Frankenberger B, et al . All transretinoic acid selectively down-regulates matrix metalloproteinase-9 (MMP-9) and up regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells [J]. Mol Med, 2001 ;7(4) :263~270

共引文献43

同被引文献117

引证文献12

二级引证文献89

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部