摘要
目的:探讨广义估计方程在临床试验重复测量资料分析中的应用。方法:利用广义估计方程分析结果指标为分类变量的重复测量资料,通过参数和标准误的估计得出统计学结论。结果:对于临床试验重复测量资料,广义估计方程能有效的考虑组内相关性,处理有缺失值的资料,可以获得中心效应的参数及其标准误的估计值,以及在考虑了中心效应之后,可以有效估计处理因素有无作用及其作用大小。结论:采用广义估计方程对临床试验重复测量资料进行统计分析,可以使药物疗效评价更为客观。
Objective:To explore the application of the generalized estimating equation (GEE)in the repeated measures data.Method:The repeated measures data were analyzed with category variance outcome by GEE and conclusions were drawn according to the estimating of parameter and standard error.Results:The method could efficiently consider the intra-class correlation,advisably deal with the missing value,correctly obtain the estimate and standard error of the each effect,by applying GEE in repeated measures data.Conclusion:It can gain more objective appraise of medication effect by the application of the GEE in the repeated measures data,and to deserve to be generalized.
出处
《现代预防医学》
CAS
北大核心
2005年第5期444-445,共2页
Modern Preventive Medicine