有机硒对神经行为发育与甲状腺功能影响观察

THE EBSELEN OF INTERVENTION EFFECT FOR NEWBORN'S DEVELOPMENT OF NERVOUS BEHAVIOR AND THROXINE

目的:通过硒对孕期干预,观察对新生儿神经行为发育和甲状腺功能调节的作用。方法:采用Ebselen对围产期铅暴露进行全程干预,应用石墨炉原子吸收光谱法等测定脐血铅、血硒及促甲状险素活性甲状腺素,在新生儿出生后第2 6～2 8d采用双盲法进行神经行为发育(NBNA)评价。结果:干预组脐血铅均值为0 . 34μmol/L ,显著低于对照组的0 . 5μmol/L ,血硒、血锌、GSH Px均高于对照组(P <0 . 0 1 ) ,TT3 、TT3 /TT4比值、FT3 /FT4比数值高于对照组(P <0 . 0 1 )。结论:采用硒干预对降低新生儿铅毒,改善微量营养素,提升抗氧化功能,改善甲状腺功能代谢,保护新生儿智力正常发育均有明显促进作用。

Objective:To explore the effect of perinatal lead intervention on the development of newborn's nervous behavior and throxineMethods:The intervention with epidemiological investigation was proceeded with the perinatal lead exposure by method and the umbilical blood selenium was detected by double ways fluoreson day using Ebselen,and the umbilical blood lead was detected by atomic absorption 26-28 days of newborn was evaluated by using double blind methodResults:The navel blood lead of intervention group was 034 μmol/L,which was lower than the control group significantly(05 μmol/L),the blood selenium,zinc and GSH-Px were all higher than the control group(P<001)TT 3,TT 3/TT 4,FT 3/FT 4 value of intervention group was higher than the coutrol groupConclusion:The perinatal lead intervention has obviously promoted the alleviation the lead toxin of newborn,improving the level of trace nutrients,enhancing the ability of antioxidation,improving the metabolize of throxine and protecting the normal development of neworn's intelligence